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NANO TECHNOLOGY FACTS

Olga Meliton Miller Nanotechnology Enterprise

WHAT IS NANOTECHNOLOGY?

Nanotechnology is a field of applied science focused on the design, synthesis, characterization and application of materials and devices on the nanoscale. Nanotechnology is a sub classification of technology in colloidal science, biology, physics, chemistry and other scientific fields and involves the study of phenomena and manipulation of material at the nanoscale, in essence an extension of existing sciences into the nanoscale. Two main approaches are used in nanotechnology: one is a "bottom-up" approach where materials and devices are built up atom by atom, the other a "top-down" approach where they are synthesized or constructed by removing existing material from larger entities. A unique aspect of nanotechnology is the vastly increased ratio of surface area to volume present in many nanoscale materials, which opens new possibilities in surface-based science, such as catalysis. This catalytic activity also opens potential risks in their interaction with biomaterials.

The ongoing quest for miniaturization has resulted in tools such as the atomic force microscope and the scanning tunneling microscope. Combined with refined processes such as electron beam lithography, these instruments allow us to deliberately manipulate and manufacture nanostructures. Engineered nanomaterials, either by way of a top-down approach (a bulk material is reduced in size to nanoscale pattern) or a bottom-up approach (larger structures are built or grown atom by atom or molecule by molecule), go beyond just a further step in miniaturization. They have broken a size barrier below which quantization of energy for the electrons in solids becomes relevant. The so-called “quantum size effect” describes the physics of electron properties in solids with great reductions in particle size. This effect does not come into play by going from macro to micro dimensions. However, it becomes dominant when the nanometer size range is reached. Materials reduced to the nanoscale can suddenly show very different properties compared to what they show on a macroscale. For instance, opaque substances become transparent (copper); inert materials become catalysts (platinum); stable materials turn combustible (aluminum); solids turn into liquids at room temperature (gold); insulators become conductors (silicon).

A second important aspect of the nanoscale is that the smaller a nanoparticle gets, the larger its ratio of surface area to volume becomes. Its electronic structure changes dramatically, too. Both effects lead to greatly improved catalytic activity but can also lead to aggressive chemical reactivity.

The fascination with nanotechnology stems from these unique quantum and surface phenomena that matter exhibits at the nanoscale, making possible novel applications and interesting materials.

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Applications of Nanotechnology

With nanotechnology, a large set of materials with distinct properties (optical, electrical, or magnetic) can be fabricated. Nanotechnologically improved products rely on a change in the physical properties when the feature sizes are shrunk. Nanoparticles for example take advantage of their dramatically increased surface area to volume ratio. Their optical properties, e.g. fluorescence, become a function of the particle diameter. When brought into a bulk material, nanoparticles can strongly influence the mechanical properties, such as the stiffness or elasticity. Example, traditional polymers can be reinforced by nanoparticles resulting in novel materials e.g. as lightweight replacements for metals. Therefore, an increasing societal benefit of such nanoparticles can be expected.

Such nanotechnologically enhanced materials will enable a weight reduction accompanied by an increase in stability and an improved functionality.

Medicine

The biological and medical research communities have exploited the unique properties of nanomaterials for various applications (e.g., contrast agents for cell imaging and therapeutics for treating cancer). Terms such as biomedical nanotechnology, bionanotechnology, and nanomedicine are used to describe this hybrid field.

Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications.

Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug-delivery vehicles.

Diagnostics

Nanotechnology-on-a-chip is one more dimension of lab-on-a-chip technology. Biological tests measuring the presence or activity of selected substances become quicker, more sensitive and more flexible when certain nanoscale particles are put to work as tags or labels. Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms. Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample. Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads. Nanopore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.

Drug delivery

The overall drug consumption and side-effects can be lowered significantly by depositing the active agent in the morbid region only and in no higher dose than needed. This highly selective approach reduces costs and human suffering. An example can be found in dendrimers and nanoporous materials. They could hold small drug molecules transporting them to the desired location. Another vision is based on small electromechanical systems: NEMS are being investigated for the active release of drugs. Some potentially important applications include cancer treatment with iron nanoparticles or gold shells.

A targeted or personalized medicine reduces the drug consumption and treatment expenses resulting in an overall societal benefit by reducing the costs to the public health system.

Tissue engineering

Nanotechnology can help to reproduce or to repair damaged tissue. This so called “tissue engineering” makes use of artificially stimulated cell proliferation by using suitable nanomaterial-based scaffolds and growth factors. Tissue engineering might replace today’s conventional treatments, e.g. transplantation of organs or artificial implants. On the other hand, tissue engineering is closely related to the ethical debate on human stem cells and its ethical implications.

Chemistry and environment

Chemical catalysis and filtration techniques are two prominent examples where nanotechnology already plays a role. The synthesis provides novel materials with tailored features and chemical properties e.g. nanoparticles with a distinct chemical surrounding (ligands) or specific optical properties. In this sense, chemistry is indeed a basic nanoscience. In a short-term perspective, chemistry will provide novel “nanomaterials” and in the long run, superior processes such as “self-assembly” will enable energy and time preserving strategies.

In a sense, all chemical synthesis can be understood in terms of nanotechnology, because of its ability to manufacture certain molecules. Thus, chemistry forms a base for nanotechnology providing tailor-made molecules, polymers etc. and furthermore clusters and nanoparticles.

Catalysis

Chemical catalysis benefits especially from nanoparticles, due to the extremely large surface to volume ratio. The application potential of nanoparticles in catalysis ranges from fuel cell to catalytic converters and photocatalytic devices. Catalysis is also important for the production of chemicals.

Filtration

A strong influence of nanochemistry on waste-water treatment, air purification and energy storage devices is to be expected. Mechanical or chemical methods can be used for effective filtration techniques. One class of filtration techniques is based on the use of membranes with suitable hole sizes, whereby the liquid is pressed through the membrane. Nanoporous membranes are suitable for a mechanical filtration with extremely small pores smaller than 10 nm (“nanofiltration”). Nanofiltration is mainly used for the removal of ions or the separation of different fluids. On a larger scale, the membrane filtration technique is named ultrafiltration, which works down to between 10 and 100 nm. One important field of application for ultrafiltration is medical purposes as can be found in renal dialysis.

Magnetic nanoparticles offer an effective and reliable method to remove heavy metal contaminants from waste water by making use of magnetic separation techniques. Using nanoscale particles increases the efficiency to absorb the contaminants and is comparatively inexpensive compared to traditional precipitation and filtration methods.

Energy

The most advanced nanotechnology projects related to energy are: storage, conversion, manufacturing improvements by reducing materials and process rates, energy saving e.g. by better thermal insulation, and enhanced renewable energy sources.

Reduction of energy consumption

A reduction of energy consumption can be reached by better insulation systems, by the use of more efficient lighting or combustion systems, and by use of lighter and stronger materials in the transportation sector. Currently used light bulbs only convert approximately 5% of the electrical energy into light. Nanotechnological approaches like light-emitting diodes (LEDs) or quantum caged atoms (QCAs) could lead to a strong reduction of energy consumption for illumination.

Increasing the efficiency of energy production

Today's best solar cells have layers of two different semiconductors stacked together to absorb light at different energies but they still only manage to use 30 percent of the Sun's energy. Commercially available solar cells have much lower efficiencies (less than 20%). Nanotechnology could help increase the efficiency of light conversion by specifically designed nanostructures. The degree of efficiency of combustion engines is not higher than 15-20% at the moment. Nanotechnology could improve combustion by designing specific catalysts with maximized surface area. Scientists have recently developed tetrad-shaped nanoparticles that, when applied to a surface, instantly transform it into a solar collector.[citation needed]

The use of more environmentally friendly energy systems

An example for an environmentally friendly form of energy is the use of fuel cells powered by hydrogen, which is ideally produced by renewable energies. Probably the most prominent nanostructured material in fuel cells is the catalyst consisting of carbon supported noble metal particles with diameters of 1- 5 nm. Suitable materials for hydrogen storage contain a large number of small nanosized pores. Therefore many nanostructured materials like nanotubes, zeolites or alanates are under investigation.

Nanotechnology can contribute to the further reduction of combustion engine pollutants by nanoporous filters, which can clean the exhaust mechanically, by catalytic converters based on nanoscale noble metal particles or by catalytic coatings on cylinder walls and catalytic nanoparticles as additive for fuels.

Recycling of batteries

Because of the relatively low energy density of batteries the operating time is limited and a replacement or recharging is needed. The huge number of spent batteries and accumulators represent a disposal problem. The use of batteries with higher energy content or the use of rechargeable batteries or supercapacitors with higher rate of recharging using nanomaterials could be helpful for the battery disposal problem.

Information and communication

Current high-technology production processes are based on traditional top down strategies, where nanotechnology has already been introduced silently. The critical length scale of integrated circuits is already at the nanoscale (50 nm and below) regarding the gate length of transistors in CPUs or DRAM devices.